Why the study?
Does isradipine compared to atenolol affect platelet function and fibrinolysis differently in male patients with mild untreated hypertension?
Population
10 male patients with mild untreated hypertension
Comparison
Isradipine 2.5 mg twice daily for 6 months vs Atenolol 100 mg daily for 6 months
Design
RCT, Randomized to either isradipine or atenolol, followed by crossover
Follow-up
6 months per treatment period
Authors
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Isradipine may be preferred over atenolol to prevent exercise-induced platelet activation in mild hypertension; extends class-specific hemostatic effects during exertion.
Does isradipine compared to atenolol affect platelet function and fibrinolysis differently in male patients with mild untreated hypertension?
Isradipine prevents exercise-induced increases in platelet activity compared to atenolol in patients with mild hypertension, despite similar blood pressure reductions.
Gleerup et al. (1995) studied this question.
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