Cardioprotective actions of human superoxide dismutase in two reperfusion models of myocardial ischaemia in the rat

Rat models of myocardial ischemia and reperfusion (in vivo left coronary artery ligation for 10 min followed by reperfusion, and isolated hearts perfused at 15% of normal flow for 30 min followed by normal flow for 20 min)

Human superoxide dismutase (h-SOD) given 1 min after occlusion and 6 h later (in vivo), or at 2.5 or 5.0 mg (isolated hearts)

Survival and myocardial creatine kinase (CK) activity (in vivo model); perfusion pressure and myocardial CK activity (isolated heart model)surrogate