Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 15, 2011CirculationOpen Access

Notch1 in Bone Marrow–Derived Cells Mediates Cardiac Repair After Myocardial Infarction

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Notch1 signaling in bone marrow-derived cells improve cardiac repair after myocardial infarction in mice?

Population

Mice models of myocardial infarction, including mice with postnatal cardiac-specific deletion of Notch1…

Comparison

Modulation of Notch1 signaling in bone… vs Wild-type bone marrow transplantation or…

Design

Preclinical

Authors

YLYuxin LiNihon UniversityYHYukio HiroiCross-Cutting CardiologySNSoeun NgoyBrigham and Women's Hospital

Discussion

Loading...

Member takes

Implication

Should not yet inform clinical practice in ischemic heart disease; extends preclinical evidence for Notch1 in murine post-MI repair.

Structured PICO

Does Notch1 signaling in bone marrow-derived cells improve cardiac repair after myocardial infarction in mice?

P
Population
Mice models of myocardial infarction, including mice with postnatal cardiac-specific deletion of Notch1, mice with global hemizygous deletion of Notch1 (N1(±)), and wild-type (WT) mice
I
Intervention
Modulation of Notch1 signaling in bone marrow-derived cells (transplantation of N1(±) bone marrow, injection of N1(±) mesenchymal stem cells, or injection of mesenchymal stem cells overexpressing Notch intracellular domain)
C
Comparator
Wild-type bone marrow transplantation or wild-type mesenchymal stem cell injection
O
Outcome
Infarct size and heart function after ischemic injurysurrogate

Notch1 signaling in bone marrow-derived cells is critical for cardiac repair after myocardial infarction, suggesting a potential therapeutic target for ischemic heart disease.

Cite This Study

Li et al. (2011) studied this question.

synapsesocial.com/papers/6a922e858356c7bfaac8007fhttps://doi.org/10.1161/circulationaha.110.947531
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mobilized bone marrow cells repair the infarcted heart, improving function and survival2001 · 2,096 citations
  2. 2Hemangiopoietin supports animal survival and accelerates hematopoietic recovery of chemotherapy‐suppressed mice2007 · 4 citations
  3. 3Activation of Notch-Mediated Protective Signaling in the Myocardium2008 · 206 citations
  4. 4Critical Role of Endothelial Notch1 Signaling in Postnatal Angiogenesis2006 · 241 citations
  5. 5Concise Review: Notch Signaling in Stem Cell Systems2006 · 399 citations