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January 1, 2012Journal of Veterinary ScienceOpen Access

Establishment and characterization of an infectious cDNA clone of a classical swine fever virus LOM strain

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Population

PK-15 cells and pigs

Comparison

Intramuscular immunization with Flc-LOM vs Parental virus LOM; challenge with virulent CSFV…

Design

Preclinical

Follow-up

35 days

Authors

GPGil-Soon ParkSLSeong-In LimAnimal and Plant Quarantine AgencySHSeung-Ho Hong

Discussion

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Implication

Flc-LOM merits further CSFV vaccine development in swine; leaves open safety and efficacy under field conditions.

Structured PICO

P
Population
PK-15 cells and pigs
I
Intervention
Intramuscular immunization with Flc-LOM (infectious cDNA clone of classical swine fever virus LOM strain)
C
Comparator
Parental virus LOM (in vitro); challenge with virulent CSFV strain SW03 (in vivo)
O
Outcome
Viral growth in vitro, safety, immunogenicity, and protection against virulent challenge in vivosurrogate

The newly established infectious cDNA clone of CSFV LOM strain (Flc-LOM) is safe, immunogenic, and protective in pigs, making it a viable vaccine candidate.

Cite This Study

Park et al. (2012) studied this question.

synapsesocial.com/papers/6a9276cf915bce628c4f3144https://doi.org/10.4142/jvs.2012.13.1.81
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