Key result
Being in the third neutrophil-lymphocyte ratio tertile increased the risk of coronary atherosclerosis (OR 2.30; 95% CI 1.15-4.43; P=0.023) and critical luminal stenosis.
Why the study?
Is a higher neutrophil-lymphocyte ratio associated with increased presence, severity, and extent of coronary atherosclerosis detected by CTA?
Observational (n=238)
Is a higher neutrophil-lymphocyte ratio associated with increased presence, severity, and extent of coronary atherosclerosis detected by CTA?
Odds Ratio: 2.3 (95% CI 1.15–4.43)
p-value: p=.023
A higher neutrophil-lymphocyte ratio is associated with a greater presence, severity, and extent of coronary atherosclerosis on CTA, suggesting its potential utility as an accessible cardiovascular risk marker.
We evaluated whether the neutrophil-lymphocyte ratio (NLR) was associated with the presence, severity, and extent of coronary atherosclerotic plaques detected by computed tomography angiography (CTA). We studied 238 patients who underwent dual-source 64-slice CTA for the assessment of coronary artery disease. Coronary arteries were evaluated on 16-segment basis and critical plaque was described as luminal narrowing >50%. In regression analysis, being in the third NLR tertile increased the risk of coronary atherosclerosis (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.15-4.43; P = .023). When the severity of coronary atherosclerosis was assessed, being in the third NLR tertile increased the risk of critical luminal stenosis (OR, 2.60; 95% CI, 1.19-5.69; P = .017). Although plaque morphology was not associated with NLR, the extent of coronary atherosclerosis was increased with higher NLR tertiles (P = .001). Our results suggest that a higher NLR may be a useful additional measure to assess cardiovascular risk in clinical practice.
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Açar et al. (2014) conducted an observational in Coronary atherosclerosis (n=238). Neutrophil-lymphocyte ratio (NLR) vs. Lower NLR tertiles was evaluated on Presence of coronary atherosclerosis (OR 2.30, 95% CI 1.15-4.43, p=.023). Being in the third neutrophil-lymphocyte ratio tertile increased the risk of coronary atherosclerosis (OR 2.30; 95% CI 1.15-4.43; P=0.023) and critical luminal stenosis.
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