November 1, 1986AJP Endocrinology and Metabolism
Calcium pump activity of sarcoplasmic reticulum in diabetic rat skeletal muscle
Key result
Streptozotocin-induced chronic diabetes in rats was associated with increased ATP-dependent Ca2+ uptake and Ca2+-stimulated ATPase activities in skeletal muscle sarcoplasmic reticulum.
Population
Rats with chronic diabetes induced by intravenous injection of streptozotocin (65 mg/kg)
Comparison
Streptozotocin-induced diabetes vs Control rats
Design
Preclinical
Follow-up
Up to 8 weeks
Authors
Discussion
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Member takes
Implication
May indicate enhanced SR calcium handling in diabetic rat muscle; leaves open relevance to human skeletal myopathy.
Structured PICO
P
Population
Rats with chronic diabetes induced by streptozotocin injection, evaluated for skeletal muscle sarcoplasmic reticulum Ca2+ pump activity.
E
Exposure
Streptozotocin-induced diabetes (with a subgroup receiving insulin administration for 2 weeks)
C
Comparator
Control rats
O
Outcome
ATP-dependent Ca2+ uptake and Ca2+-stimulated ATPase activities in skeletal muscle microsomessurrogate
In a rat model, streptozotocin-induced diabetes enhances sarcoplasmic reticular Ca2+ pump activity, which may explain skeletal muscle hyperfunction in this condition.
Cite This Study
Ganguly et al. (1986) studied Chronic diabetes. Streptozotocin-induced chronic diabetes vs. Control rats was evaluated on ATP-dependent Ca2+ uptake and Ca2+-stimulated ATPase activities. Streptozotocin-induced chronic diabetes in rats was associated with increased ATP-dependent Ca2+ uptake and Ca2+-stimulated ATPase activities in skeletal muscle sarcoplasmic reticulum.