Key result
Endothelin and its antagonist BQ-123 demonstrated that up to 50% of the total force-generating capacity of isolated cardiac tissue is sensitive to endothelin produced by endothelial cells.
Population
Isolated rat ventricular trabeculae
Comparison
Endothelin and BQ-123 vs Tissues with different levels of contractility…
Design
Preclinical
Authors
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Hypothesis-generating for endothelin modulation in contractility; leaves open translation from isolated tissue to human disease.
Basal secretion of endothelin by endothelial cells plays a substantial role in regulating cardiac contractility in isolated rat ventricular tissue.
McClellan et al. (1995) studied Cardiac contractility. Endothelin and BQ-123 was evaluated on Changes in contractility (developed force). Endothelin and its antagonist BQ-123 demonstrated that up to 50% of the total force-generating capacity of isolated cardiac tissue is sensitive to endothelin produced by endothelial cells.