Why the study?
Do salt-sensitive rats exhibit greater central nervous system pressor responses to hypertonic saline and angiotensin II compared to salt-resistant rats?
Population
Salt-sensitive (S) and salt-resistant (R) rats on a low Na diet
Comparison
Intracerebroventricular administration of… vs Salt-resistant (R) rats
Design
Preclinical
Authors
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Central hypersensitivity may drive salt-sensitive hypertension in rats; leaves open translation to human mechanisms or therapy.
Do salt-sensitive rats exhibit greater central nervous system pressor responses to hypertonic saline and angiotensin II compared to salt-resistant rats?
Heightened central nervous system pressor responses to angiotensin II and hypertonic saline may partially account for NaCl-induced hypertension in salt-sensitive rats.
Ikeda et al. (1978) studied this question.
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