Why the study?
The prognostic significance of left ventricular diastolic dysfunction severity in patients with dilated cardiomyopathy remained uncertain.
Does elevated left atrial pressure and moderate to severe left ventricular diastolic dysfunction worsen prognosis in stable patients with dilated cardiomyopathy?
Population
644 stable, non-acutely decompensated patients with DCM
Comparison
LVDD severity and elevated left atrial pressure vs normal left atrial pressure
Design
Single-centre retrospective observational study
Follow-up
Median 41 (18.5-66.7) months
Key result
Elevated left atrial pressure was associated with higher all-cause mortality compared to normal pressure in patients with dilated cardiomyopathy (19.6% vs 5.3%; HR 2.0; 95% CI 1.1-3.7; P=0.01).
Authors
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May refine mortality risk stratification beyond LVEF in dilated cardiomyopathy; leaves open therapeutic implications pending prospective validation.
Observational (n=644)
No
Does elevated left atrial pressure and moderate to severe left ventricular diastolic dysfunction worsen prognosis in stable patients with dilated cardiomyopathy?
Hazard Ratio: 2 (95% CI 1.1–3.7)
Absolute Event Rate: 19.6% vs 5.3%
p-value: p=0.01
Elevated left atrial pressure and moderate to severe left ventricular diastolic dysfunction provide incremental prognostic information over LVEF for mortality in patients with dilated cardiomyopathy.
Winiarczyk et al. (2024) conducted an observational in Dilated cardiomyopathy (n=644). Elevated left atrial pressure (eLAP) vs. Normal left atrial pressure (nLAP) was evaluated on All-cause mortality (HR 2.0, 95% CI 1.1-3.7, p=0.01). Elevated left atrial pressure was associated with higher all-cause mortality compared to normal pressure in patients with dilated cardiomyopathy (19.6% vs 5.3%; HR 2.0; 95% CI 1.1-3.7; P=0.01).
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