Key result
Among Chinese patients treated with amiodarone, the incidence of proarrhythmic events was 19.3%, while the incidence of Torsade de pointes or ventricular fibrillation was 0.17%.
Why the study?
What is the incidence and clinical profile of amiodarone-associated Torsade de Pointes in Chinese patients?
Population
2,454 Chinese patients, comprising 100 patients with amiodarone-associated Torsade de Pointes from case…
Design
Systematic_review
Follow-up
at least 1 month
Authors
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Highlights need for proarrhythmia monitoring with amiodarone in Chinese patients; extends ethnicity-specific safety data from systematic evidence.
Systematic Review (n=2,454)
Yes
What is the incidence and clinical profile of amiodarone-associated Torsade de Pointes in Chinese patients?
While amiodarone-induced proarrhythmic events are relatively common in Chinese patients, the incidence of Torsade de Pointes or ventricular fibrillation is remarkably low (0.17%), though it carries a high mortality when it occurs, particularly in females with predisposing factors.
Geng et al. (2006) conducted a systematic review in Amiodarone-associated Torsade de Pointes (n=2,454). Amiodarone was evaluated on Torsade de pointes or ventricular fibrillation. Among Chinese patients treated with amiodarone, the incidence of proarrhythmic events was 19.3%, while the incidence of Torsade de pointes or ventricular fibrillation was 0.17%.
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