Key result
Mild-to-moderate essential hypertension was associated with increased carotid wall inertia, which significantly correlated with intima-media thickness (r = 0.61, P < 0.05).
Cross-Sectional (n=22)
Increased arterial wall inertia is associated with higher carotid intima-media thickness in hypertensive patients, suggesting a link between vascular hypertrophy and inertial behavior.
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May indicate hypertensive vascular remodeling; leaves open whether carotid inertia predicts events or guides therapy.
OBJECTIVE: The aim of this study is to evaluate the relationship between carotid intima-media thickness (IMT) and arterial wall inertial behaviour. METHODS: The simultaneous and noninvasive assessment of the intima-media complex and arterial diameter waveform was performed using high-resolution ultrasonography. The common carotid artery of eleven normotensive subjects (NTA) and eleven mild-to-moderate essential hypertensive patients (HTA) were measured noninvasively using tonometry and an automatic densitometric analysis of B-mode images to obtain IMT and instantaneous pressure (P) and diameter (D) loops. A linear discrete time model was used to estimate the inertial index (K(M)) using a system modelling-identification approach. RESULTS: In NTA K(M) was 0.333+/-0.256 (mmHg x s2/mm) and IMT 0.643+/-0.061 (mm), whereas in HTA K(M) was 0.798+/-0.590 (P < 0.05) and IMT 0.760+/-0.034 (P < 0.025). When all data of K(M) versus IMT of NTA and HTA were pooled in a linear regression analysis, a correlation coefficient of r = 0.61 (P < 0.05) was obtained. CONCLUSION: Wall inertia increase was associated with a higher IMT, suggesting that the intima-media thickening might be partially related to vascular hypertrophy manifested as increase of inertial behaviour.
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Gamero et al. (1999) conducted a cross-sectional in Hypertension (n=22). Mild-to-moderate essential hypertension vs. Normotension was evaluated on Correlation between inertial index (K(M)) and intima-media thickness (IMT) (r = 0.61, p=< 0.05). Mild-to-moderate essential hypertension was associated with increased carotid wall inertia, which significantly correlated with intima-media thickness (r = 0.61, P < 0.05).
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