Key result
Intrabrachial clonidine infusion caused a dose-dependent maximum reduction in forearm blood flow of 32% (p<0.01) but did not significantly change norepinephrine spillover in healthy volunteers.
Why the study?
Does clonidine infusion modulate norepinephrine release in the forearm vasculature of healthy subjects?
Population
13 normal volunteers
Design
Other
Authors
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Clonidine reduces forearm blood flow without altering norepinephrine spillover; leaves open whether prejunctional α2-autoinhibition modulates local release in healthy vasculature.
Does clonidine infusion modulate norepinephrine release in the forearm vasculature of healthy subjects?
p-value: p=<0.01
Autoinhibitory feedback control via prejunctional alpha 2-adrenoceptors may not significantly modulate norepinephrine release in the forearm vasculature of healthy subjects.
Kiowski et al. (1985) studied Healthy subjects (n=13). Intrabrachial artery clonidine infusion was evaluated on Forearm blood flow (FAF) and norepinephrine spillover (p=<0.01). Intrabrachial clonidine infusion caused a dose-dependent maximum reduction in forearm blood flow of 32% (p<0.01) but did not significantly change norepinephrine spillover in healthy volunteers.
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