Key result
High physical activity prevented the acute increase in systemic arterial stiffness observed in inactive individuals following glucose ingestion in older adults with impaired glucose tolerance.
Why the study?
It was unclear whether physical activity is associated with arterial stiffness after glucose intake in older adults with impaired glucose tolerance.
Does high physical activity prevent the acute increase in arterial stiffness during hyperglycemia in older adults with impaired glucose tolerance?
Cross-Sectional (n=20)
No
Does high physical activity prevent the acute increase in arterial stiffness during hyperglycemia in older adults with impaired glucose tolerance?
p-value: p=<0.01
Habitual physical activity (approximately 10,000 steps/day) may prevent the acute increase in systemic arterial stiffness typically observed during postprandial hyperglycemia in older adults with impaired glucose tolerance.
Should not alter practice; hypothesis-generating for trials on activity and postprandial stiffness in IGT.
We compared arterial stiffness after glucose intake in active and inactive elderly people with impaired glucose tolerance and clarified whether physical activity was associated with arterial stiffness after ingestion of glucose. Twenty older adults with impaired glucose tolerance were analyzed in a cross-sectional design. Based on the international physical activity questionnaire, participants were divided into the active group (daily step count: 10,175.9 ± 837.8 steps/day, n = 10) or the inactive group (daily step count: 4,125.6 ± 485.9 steps/day, n = 10). Brachialankle (systemic) and heartbrachial (aortic) pulse wave velocity and cardio-ankle vascular index (systemic) were increased at 30, 60, and 90 min compared to baseline after a 75-g oral glucose tolerance test in the inactive but not the active group. Heartbrachial pulse wave velocity did not change compared to baseline after a 75-g oral glucose tolerance test in either group. The area under the curve for brachialankle pulse wave velocity was associated with daily living activity (r = –0.577, p = 0.008), daily step activity (r = –0.546, p = 0.013), and the daily step count (r = –0.797, p = 0.0001). The present findings indicate that physical activity or inactivity is associated with arterial stiffness following glucose ingestion.
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Kobayashi et al. (2019) conducted a cross-sectional in Impaired glucose tolerance (n=20). High physical activity vs. Low physical activity was evaluated on Brachial-ankle pulse wave velocity (baPWV) area under the curve (AUC) after 75-g OGTT (p=<0.01). High physical activity prevented the acute increase in systemic arterial stiffness observed in inactive individuals following glucose ingestion in older adults with impaired glucose tolerance.
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