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January 1, 1945Experimental Biology and Medicine

Poliomyelitis Virus in the Blood Stream in the Experimental Disease.

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Population

10 monkeys paralyzed after being inoculated with poliomyelitis virus of recent human origin

Design

Preclinical

Authors

JMJ. L. MelnickBaylor College of Medicine

Discussion

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Implication

Suggests viremia in some paralyzed monkeys; leaves open human relevance and clinical implications.

Key Points

  • To determine whether poliomyelitis virus of recent human origin enters the systemic circulation and gastrointestinal tract during experimental paralytic infection.
  • Inoculated 10 monkeys (including rhesus and capuchin species) with human-origin poliomyelitis virus to induce paralytic disease.
  • Tested bloodstream samples from all 10 paralyzed animals for the presence of circulating virus.
  • Assayed colon contents for viral presence in subsets of animals with and without detectable viremia.
  • Detected poliomyelitis virus in the bloodstream of 4 of 10 paralyzed monkeys (3 rhesus and 1 capuchin), with all positive blood isolates attributable to a single viral strain.
  • Identified virus in colon contents in 1 of 3 tested monkeys with detectable viremia, and in 1 of 4 monkeys without detectable virus in the bloodstream.

Structured PICO

P
Population
10 monkeys (rhesus and capuchin) paralyzed after being inoculated with poliomyelitis virus of recent human origin
I
Intervention
Inoculation with poliomyelitis virus
O
Outcome
Presence of poliomyelitis virus in the blood streamsurrogate

Demonstrates that poliomyelitis virus can be detected in the blood stream of experimentally infected monkeys.

Cite This Study

J. L. Melnick (1945) studied this question.

synapsesocial.com/papers/6a986aae381c17dc98d997d2https://doi.org/10.3181/00379727-58-14821
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliomyelitis Virus in Blood of Orally Infected Monkeys and Chimpanzees.1952 · 83 citations
  2. 2EXPERIMENTAL POLIOMYELITIS IN MONKEYS1910 · 61 citations
  3. 3NATURE OF NON-PARALYTIC AND TRANSITORY PARALYTIC POLIOMYELITIS IN RHESUS MONKEYS INOCULATED WITH HUMAN VIRUS1941 · 41 citations
  4. 4EPIDEMIC POLIOMYELITIS IN MONKEYS1910 · 13 citations
  5. 5Evidence of Possible Occurrence of Anaphylactic Phenomena in Poliomyelitis Immune Monkeys.1932 · 1 citations