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April 1, 1992Journal of Cardiovascular Pharmacology

Combination of Nifedipine and Doxazosin in Essential Hypertension

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Why the study?

Does the combination of nifedipine and doxazosin improve blood pressure control in hypertensive patients with suboptimal response to monotherapy?

Population

Hypertensive patients in whom blood pressure control was suboptimal after doxazosin or nifedipine as…

Comparison

Combination of nifedipine and doxazosin for 4… vs Monotherapy plus placebo

Design

Other

Follow-up

4 weeks

Authors

RDRichard DonnellyHEHenry L. ElliottPMPeter Meredith

Discussion

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Overview

May aid BP lowering after monotherapy failure; leaves open outcome benefits and needs confirmation in larger trials.

Structured PICO

Does the combination of nifedipine and doxazosin improve blood pressure control in hypertensive patients with suboptimal response to monotherapy?

P
Population
Hypertensive patients in whom blood pressure control was suboptimal after doxazosin (group A) or nifedipine (group B) as monotherapy
I
Intervention
Combination of nifedipine (20 mg twice daily) and doxazosin (2 mg once daily) for 4 weeks
C
Comparator
Monotherapy plus placebo (doxazosin + placebo for group A, nifedipine + placebo for group B)
O
Outcome
Average supine blood pressure over 8 hourssurrogate

The combination of doxazosin and nifedipine provides effective additional blood pressure reduction without adverse pharmacokinetic interactions in patients with essential hypertension.

Cite This Study

Donnelly et al. (1992) studied this question.

synapsesocial.com/papers/6a98dcbf74b439c6a5aef50chttps://doi.org/10.1097/00005344-199204000-00002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Nifedipine Alone and With Diltiazem or Verapamil in Hypertension1996 · 82 citations
  2. 2Captopril and Nifedipine Interactions in the Treatment of Essential Hypertensives: A Crossover Study1987 · 46 citations
  3. 3Unmasking of the hypotensive effect of nifedipine in normotensives by addition of the angiotensin converting enzyme inhibitor benazepril1992 · 11 citations
  4. 4Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.1980 · 165 citations
  5. 5Nifedipine tablet vs. hydralazine in patients with persisting hypertension who receive combined diuretic and beta-blocker therapy1986 · 11 citations