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May 1, 1980CirculationOpen Access

Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.

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Why the study?

Does nifedipine combined with methyldopa reduce blood pressure in patients with severe hypertension?

Population

29 subjects, including 23 with uncomplicated primary severe hypertension and 6 with very severe hypertension…

Comparison

Nifedipine combined with methyldopa. vs Nifedipine alone (during short-term testing).

Design

Case_series

Follow-up

12 months

Authors

MGMarco GuazziCFCesare FiorentiniMOM. T. Olivari

Discussion

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Overview

May support short-term BP control with nifedipine-methyldopa in severe hypertension; leaves open confirmation in prospective trials.

Structured PICO

Does nifedipine combined with methyldopa reduce blood pressure in patients with severe hypertension?

P
Population
29 subjects, including 23 with uncomplicated primary severe hypertension (diastolic pressure > 120 mm Hg) and 6 with very severe hypertension (diastolic pressure > 140 mm Hg) complicated by cardiac failure.
I
Intervention
Nifedipine (10 mg orally every 4 to 6 hours) combined with methyldopa (250 mg four times daily).
C
Comparator
Nifedipine alone (during short-term testing).
O
Outcome
Blood pressure reduction.surrogate

The combination of nifedipine and methyldopa provides effective short- and long-term blood pressure reduction in patients with severe hypertension.

Cite This Study

Guazzi et al. (1980) studied this question.

synapsesocial.com/papers/6a8a85eb6fc170cbc2fbf75ahttps://doi.org/10.1161/01.cir.61.5.913
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypotensive action of nifedipine (Ca2+-antagonist) and propranolol in acute trials and its long-term therapy of hypertensive coronary heart disease patients.1981 · 11 citations
  2. 2Nitrendipine vs. Long-Acting Nifedipine in Mild, Moderate and Severe Hypertension1986 · 9 citations
  3. 3Nifedipine in the Treatment of Essential Hypertension1985 · 10 citations
  4. 4Use of Nifedipine as an Adjunct to Current Antihypertensive Therapy1984 · 28 citations
  5. 5Antihypertensive and Humoral Effects of Nifedipine in Essential Hypertension Nifedipine in Essential Hypertension1989 · 4 citations