Key result
Diltiazem significantly reduced tissue malondialdehyde content in reperfused isolated rabbit hearts compared with control (1.54 vs 3.57 nmol/g, p<0.05).
Why the study?
Does diltiazem reduce lipid peroxidation in reperfused isolated rabbit hearts?
Population
Isolated rabbit hearts perfused with buffer under control conditions or after 60 minutes of ischemia with or…
Comparison
Diltiazem (5 x 10(-7)M) vs Reperfusion without drug (control)
Design
Preclinical
Follow-up
60 minutes of ischemia and 3 minutes of reperfusion
Authors
Loading...
May attenuate oxidative stress in reperfused myocardium; hypothesis-generating for cardioprotection mechanisms, with human translation unproven.
Does diltiazem reduce lipid peroxidation in reperfused isolated rabbit hearts?
Absolute Event Rate: 1.54% vs 3.57%
p-value: p=<0.05
Diltiazem reduces lipid peroxidation in reperfused isolated rabbit hearts, suggesting a mechanism for myocardial salvage independent of free radical scavengers.
Koller et al. (1989) studied Myocardial ischemia/reperfusion injury (n=29). Diltiazem vs. Buffer without drug was evaluated on Tissue malondialdehyde (MDA) content (p=<0.05). Diltiazem significantly reduced tissue malondialdehyde content in reperfused isolated rabbit hearts compared with control (1.54 vs 3.57 nmol/g, p<0.05).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: