Key result
BHT-933 5 mg significantly lowered supine (99/64 vs 116/73) and standing (92/67 vs 114/79) blood pressure compared to placebo in normotensive men.
Why the study?
Does BHT-933 lower blood pressure in male normotensive volunteers?
Population
9 male normotensive volunteers
Comparison
BHT-933 5 mg vs Placebo
Design
RCT, random order
Follow-up
3-4 hours
Authors
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BHT-933 lowers BP in normotensive men; confirms central alpha2-adrenoceptor agonism as antihypertensive mechanism.
RCT (n=9)
Random order
Does BHT-933 lower blood pressure in male normotensive volunteers?
Absolute Event Rate: 99% vs 116%
BHT-933, a specific alpha 2-adrenoceptor agonist, significantly lowers blood pressure and plasma noradrenaline in normotensive men, consistent with central alpha 2-receptor action.
Rubin et al. (1982) conducted an RCT in Normotension (n=9). BHT-933 vs. Placebo was evaluated on Supine systolic blood pressure. BHT-933 5 mg significantly lowered supine (99/64 vs 116/73) and standing (92/67 vs 114/79) blood pressure compared to placebo in normotensive men.
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