Key result
A rapid rule-out myocardial infarction protocol using serial CK-MB(mass) reduced median emergency room length of stay from 16.0 to 9.0 hours (p<0.0001) with similar 30-day event rates (0.7% vs 0.9%).
Why the study?
Does a rapid rule-out myocardial infarction protocol using serial CK-MB(mass) reduce length of stay without increasing adverse events compared to CK-MB(activity) in patients with chest pain?
Cohort (n=653)
No
Does a rapid rule-out myocardial infarction protocol using serial CK-MB(mass) reduce length of stay without increasing adverse events compared to CK-MB(activity) in patients with chest pain?
Absolute Event Rate: 0.7% vs 0.9%
A rapid rule-out MI protocol using serial CK-MB(mass) significantly reduces emergency room length of stay without increasing the risk of cardiac death or MI compared to CK-MB(activity).
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May shorten emergency stays with serial CK-MB(mass) without raising events; leaves open randomized confirmation versus modern troponin protocols.
Radha Bholasingh (2001) conducted a cohort in chest pain (n=653). Rapid rule-out myocardial infarction protocol using serial CK-MB(mass) assay vs. Rule-out protocol using CK-MB(activity) assay was evaluated on Combined incidence of cardiac death and acute myocardial infarction at 30 days. A rapid rule-out myocardial infarction protocol using serial CK-MB(mass) reduced median emergency room length of stay from 16.0 to 9.0 hours (p<0.0001) with similar 30-day event rates (0.7% vs 0.9%).
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