October 1, 2000Pacing and Clinical Electrophysiology
Closed‐Loop Stimulation Using Intracardiac Impedance as a Sensor Principle: Correlation of Right Ventricular dP/dtmax and Intracardiac Impedance During Dobutamine Stress Test
Key result
Intracardiac impedance signals closely correlated with right ventricular dP/dtmax during dobutamine stress testing for both ventricular paced (r2 = 0.93) and intrinsic rhythms (r2 = 0.92).
Why the study?
Does intracardiac impedance correlate with right ventricular dP/dtmax during dobutamine stress testing in patients undergoing pacemaker implantation?
Population
12 patients (10 men, mean age 68 +/- 12 years) undergoing implantation of an Inos2 DDDR pacemaker
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports impedance sensing for rate-adaptive pacing; leaves open prospective outcome validation in closed-loop systems.
Structured PICO
Does intracardiac impedance correlate with right ventricular dP/dtmax during dobutamine stress testing in patients undergoing pacemaker implantation?
P
Population
12 patients (mean age 68 years, 17% female) undergoing implantation of an Inos2 DDDR pacemaker who underwent a dobutamine stress test.
I
Intervention
Dobutamine stress test (stepwise increase 5-20 micrograms/kg per min) with simultaneous measurement of RV-dP/dtmax via pigtail catheter and ventricular impedance (VIMP) signals
O
Outcome
Correlation between normalized values of RV-dP/dtmax and VIMPsurrogate
Main Result
Effect estimate: r2 = 0.93 (paced), r2 = 0.92 (intrinsic)
Intracardiac impedance closely correlates with right ventricular dP/dtmax during dobutamine stress testing, suggesting it is a highly accurate sensor principle for physiological rate adaptation in closed-loop pacing systems.
Cite This Study
Osswald et al. (2000) studied Patients requiring pacemaker implantation (n=12). Dobutamine stress test with intracardiac impedance measurement was evaluated on Correlation between RV-dP/dtmax and ventricular impedance (VIMP) (r2 = 0.93 (paced), r2 = 0.92 (intrinsic)). Intracardiac impedance signals closely correlated with right ventricular dP/dtmax during dobutamine stress testing for both ventricular paced (r2 = 0.93) and intrinsic rhythms (r2 = 0.92).