Key result
Functional response to CRT-D (LVEF ≥35%) was associated with 0% all-cause mortality compared to 22% in nonresponders (P=0.003), and 0% appropriate shocks compared to 17% (P=0.003).
Why the study?
Does functional response to CRT-D improve clinical outcomes and reduce appropriate shocks in patients with chronic heart failure?
Population
142 consecutive chronic heart failure patients who received CRT-D as primary prevention, with complete data…
Comparison
Functional response to CRT-D vs Functional nonresponse to CRT-D
Design
Cohort
Follow-up
median 3.0 years (IQR 1.6-4.4)
Authors
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CRT-D responders may have negligible arrhythmic risk; leaves open whether LVEF response can safely guide ICD decisions in prospective trials.
Cohort (n=142)
No
Does functional response to CRT-D improve clinical outcomes and reduce appropriate shocks in patients with chronic heart failure?
Absolute Event Rate: 0% vs 22%
p-value: p=0.003
Patients with chronic heart failure who achieve an LVEF ≥35% after CRT-D implantation have excellent clinical outcomes and rarely require ICD therapy.
Boven et al. (2012) conducted a cohort in Chronic heart failure (CHF) (n=142). Functional response to CRT-D (LVEF ≥ 35% postimplantation) vs. Functional nonresponse (LVEF < 35% postimplantation) was evaluated on All-cause mortality (p=0.003). Functional response to CRT-D (LVEF ≥35%) was associated with 0% all-cause mortality compared to 22% in nonresponders (P=0.003), and 0% appropriate shocks compared to 17% (P=0.003).
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