Key result
Treatment with cyclosporin/azathioprine was closely associated with a higher ejection fraction both at rest and on exercise one year after cardiac transplantation.
Why the study?
Does cyclosporin/azathioprine compared to prednisolone/azathioprine improve left ventricular systolic function in cardiac transplant recipients one year after operation?
Observational (n=107)
Does cyclosporin/azathioprine compared to prednisolone/azathioprine improve left ventricular systolic function in cardiac transplant recipients one year after operation?
Left ventricular systolic function is well maintained one year after cardiac transplantation, with higher ejection fractions associated with cyclosporin/azathioprine immunosuppression.
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May favor cyclosporin/azathioprine for LV function preservation post-transplant; leaves open randomized comparison with prednisolone regimens.
Reid et al. (1988) conducted an observational in Cardiac transplantation (n=107). Cyclosporin/azathioprine vs. Prednisolone/azathioprine was evaluated on Left ventricular systolic function (ejection fraction). Treatment with cyclosporin/azathioprine was closely associated with a higher ejection fraction both at rest and on exercise one year after cardiac transplantation.
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