Key result
The ABIOMED polymeric trileaflet valve demonstrated improved leaflet motion and pressure drop versus tissue valves, but was more stenotic than low-profile mechanical valves in in vitro testing.
Why the study?
Does the ABIOMED polymeric trileaflet valve prosthesis improve fluid dynamic performance compared to existing tissue and mechanical valves in an in vitro model?
Does the ABIOMED polymeric trileaflet valve prosthesis improve fluid dynamic performance compared to existing tissue and mechanical valves in an in vitro model?
Answers are grounded in this paper and cite their sources.
In vitro testing of the ABIOMED polymeric trileaflet valve reveals superior fluid dynamics compared to tissue valves but greater stenosis than mechanical valves, highlighting areas for design optimization.
The need for better and longer lasting trileaflet valves has led to the design and development of the ABIOMED polymeric trileaflet valve prosthesis. In vitro fluid dynamic studies in the aortic position indicate that overall it has improved leaflet motion characteristics and pressure drop characteristics compared to the Carpentier-Edwards porcine and Ionescu-Shiley pericardial tissue valves in current clinical use. The ABIOMED valve is, however, more stenotic compared to the St. Jude and Medtronic-Hall low profile mechanical valves, at normal cardiac outputs. Steady and pulsatile flow velocity measurements with a laser-Doppler anemometer system indicate that the flow field downstream of the ABIOMED valve is jet-like and leads to elevated shear stresses. These shear stresses are, however, lower than those observed with the Ionescu-Shiley and Carpentier-Edwards tissue valves. The ABIOMED valves tested had been originally configured for use in valved conduits, and it is therefore our opinion that further improvements can be made to the valve and stent design which would enhance its fluid dynamic performance.
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Woo et al. (1983) studied this question. ABIOMED polymeric trileaflet valve prosthesis vs. Carpentier-Edwards porcine, Ionescu-Shiley pericardial, St. Jude, and Medtronic-Hall valves was evaluated on Fluid dynamic characteristics (leaflet motion, pressure drop, shear stresses). The ABIOMED polymeric trileaflet valve demonstrated improved leaflet motion and pressure drop versus tissue valves, but was more stenotic than low-profile mechanical valves in in vitro testing.
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