Key result
Vagal blockade combined with decerebellation resulted in a significant reversible inhibition of the peak integral of EMGdi response during inspiratory tracheal occlusion (P<0.05).
Why the study?
Does decerebellation affect respiratory load compensation during tracheal occlusion in anesthetized cats?
Population
16 anesthetized cats
Comparison
Decerebellation with and without vagal input vs Baseline (before decerebellation)
Design
Preclinical
Authors
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Findings from anesthetized cats should not change practice; leaves open cerebellar contributions to human respiratory load compensation.
Does decerebellation affect respiratory load compensation during tracheal occlusion in anesthetized cats?
p-value: p=<0.05
The cerebellum plays a role in determining the pattern of the respiratory response to tracheal occlusion, likely via interaction with suprapontine, vagal, and nonvagal sources.
Xu et al. (1993) studied Respiratory load compensation (animal model) (n=16). Decerebellation and vagal blockade vs. Baseline (intact preparation) was evaluated on Peak integrated diaphragm electromyographic (integral of EMGdi) response during inspiratory tracheal occlusion (p=<0.05). Vagal blockade combined with decerebellation resulted in a significant reversible inhibition of the peak integral of EMGdi response during inspiratory tracheal occlusion (P<0.05).
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