Key result
Retrograde intracoronary SOD preserves LVEF at ~71% and reduces infarct size versus intravenous delivery.
Why the study?
Does retrograde intracoronary infusion of SOD improve cardioprotection against reperfusion injury compared to intravenous administration in a rat model?
Does retrograde intracoronary infusion of SOD improve cardioprotection against reperfusion injury compared to intravenous administration in a rat model?
Absolute Event Rate: 71.3% vs 60.8%
p-value: p=0.028
Retrograde intracoronary infusion of SOD provides superior cardioprotection against ischemia-reperfusion injury compared to intravenous administration in a rat model.
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Should not change clinical reperfusion strategies; hypothesis-generating for retrograde intracoronary antioxidant delivery in ischemia-reperfusion models.
Fukushima et al. (2005) studied Ischemia-reperfusion injury. Retrograde intracoronary infusion of CuZn-SOD vs. Intravenous CuZn-SOD (15,000 U/kg) or phosphate buffer saline was evaluated on Left ventricular ejection fraction (LVEF) (p=0.028). Retrograde intracoronary infusion of SOD significantly preserved left ventricular ejection fraction (71.3% vs 60.8%, p=0.028) and reduced infarct size compared to intravenous administration.
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