Key result
Age-dependent Na+/K+ pump dysfunction impairs myocardial contractility and drives brain tissue dysfunction via reverse Na+/Ca2+ exchange.
Why the study?
It was unknown whether the brain cortex or heart muscle primarily fails as a result of age-sensitive metabolic dysfunction associated with tissue dehydration.
Age-dependent impairment of heart muscle contractility via Na+/K+ pump dysfunction may primarily drive the overexpression of Na+/Ca2+ exchanger in brain cortex tissues.
Answers are grounded in this paper and cite their sources.
Brain or heart tissue hydration may show differential age-related metabolic sensitivity; leaves open which organ fails first and requires clinical validation.
The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
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Narinyan et al. (2019) studied Age-dependent impairment of heart muscle contractility. Metabolic manipulation (cooling, distilled water, Na+/K+ pump inactivation) was evaluated on Cell hydration in brain cortex and heart muscle tissues. Age-dependent dysfunction of Na+/K+ pump-induced activation of reverse Na+/Ca2+ exchange impairs heart muscle contractility, serving as a primary mechanism for brain tissue dysfunction.
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