What is the clinical evidence from this study?

Study design: Other. Population: Arterial hypertension (n=14). Intervention: Indapamide vs. Baseline. Primary outcome: Supine systolic blood pressure (mmHg) (p=<0.01).

January 1, 1983Japanese Heart JournalOpen Access

Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.

Q: What are the key findings of this study?

Indapamide 2.5 mg once daily significantly reduced supine systolic blood pressure from 167 to 148 mmHg and diastolic blood pressure from 109 to 94 mmHg in hypertensive men.

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Key result

Indapamide daily linked to a ~19 mmHg reduction in supine SBP in hypertensive men.

P<0.01
n=14

Why the study?

Does indapamide 2.5 mg once daily reduce blood pressure and improve hemodynamics in men with mild to moderate hypertension?

Population

14 male patients with uncomplicated mild to moderate arterial hypertension, age 30-60 years, without…

Design

Cohort

Follow-up

8 weeks on treatment, plus 2 weeks after withdrawal

Authors

LFL FerraraPolitecnico di Milano DGD GiumettiUniversity of Naples Federico II MFMaria Luisa FasanoGeological Survey of Norway

Discussion

Member takes

Implication

Should not yet change practice; leaves open confirmation of hemodynamic benefits in larger randomized cohorts.

Structured PICO

Does indapamide 2.5 mg once daily reduce blood pressure and improve hemodynamics in men with mild to moderate hypertension?

Population

14 male patients aged 30 to 60 years with mild to moderate uncomplicated hypertension were treated with indapamide and followed for 8 weeks.

Intervention

Indapamide 2.5 mg oral once a day for 8 weeks, after discontinuation of previous antihypertensive treatment.

Outcome

Changes in systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), cardiac function (cardiac work, systolic time intervals), and peripheral arterial resistance (PAR) at 8 weeks.surrogate

Main Result

Absolute Event Rate: 148% vs 167%

p-value: p=<0.01

Indapamide 2.5 mg daily effectively lowers blood pressure and peripheral resistance without causing reflex tachycardia, suggesting it may antagonize the cardiovascular effects of catecholamines.

Limitations

Small sample size of only 14 patients
Lack of a parallel control group (single-arm before-after design)
Short follow-up duration of 8 weeks
Study population restricted to male patients only
Small sample size (n=14 total, and only n=7 for calf rest flow measurements)

Cite This Study

Ferrara et al. (1983) studied Arterial hypertension (n=14). Indapamide vs. Baseline was evaluated on Supine systolic blood pressure (mmHg) (p=<0.01). Indapamide 2.5 mg once daily significantly reduced supine systolic blood pressure from 167 to 148 mmHg and diastolic blood pressure from 109 to 94 mmHg in hypertensive men.

synapsesocial.com/papers/6aa436f35b75cc9dd9c97c04 https://doi.org/10.1536/ihj.24.731

Topics

Hypertension management

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Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider