Key result
Oral lofexidine dose-dependently lowers arterial pressure and heart rate, reducing urinary noradrenaline by ~28%.
Why the study?
Does lofexidine reduce arterial pressure and heart rate in patients with essential hypertension?
Does lofexidine reduce arterial pressure and heart rate in patients with essential hypertension?
Lofexidine is an effective antihypertensive agent that produces dose-related decreases in blood pressure and heart rate, though it is associated with sedation, orthostatic dizziness, and fluid retention.
Answers are grounded in this paper and cite their sources.
Lofexidine may warrant study in essential hypertension; leaves open clinical utility pending controlled trials.
1 Single oral doses of lofexidine, 0.1, 0.3, and 0.6 mg produced dose related decreases in supine and standing arterial pressure and heart rate in nineteen patients with essential hypertension. 2 A mean oral antihypertensive threshold dose of less than 0.1 mg was estimated. 3 Lofexidine decreased mean urinary noradrenaline excretion 28% and caused significant retention of sodium and water. 4 The most prominent side effects were sedation and orthostatic dizziness. 5 Lofexidine is pharmacologically similar to, but apparently less potent than clonidine as an antihypertensive agent.
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Fagan et al. (1982) studied essential hypertension (n=19). Lofexidine was evaluated on Supine and standing arterial pressure and heart rate. Single oral doses of lofexidine (0.1, 0.3, and 0.6 mg) produced dose-related decreases in arterial pressure and heart rate, and decreased mean urinary noradrenaline excretion by 28%.
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