What does this research mean for the field?

Growth hormone-deficient adults with low serum IGF-I concentrations exhibit greater orderliness of growth hormone secretion compared to those with normal IGF-I levels and healthy controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 2002The Journal of Clinical Endocrinology & MetabolismOpen Access

Increased Orderliness of Growth Hormone (GH) Secretion in GH-Deficient Adults with Low Serum Insulin-Like Growth Factor I

Q: What are the key findings of this study?

GH-deficient adults with low IGF-I levels exhibited lower ApEn ratios, denoting greater orderliness of GH secretion, compared to those with normal IGF-I and healthy controls (P<0.01 and P<0.05).

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Growth Hormone Deficiency (n=15). Intervention: Low serum IGF-I vs. Normal serum IGF-I and healthy controls. Primary outcome: Approximate entropy (ApEn) ratios of 24-h GH secretion (p=<0.01 and <0.05).

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Key result

GH-deficient adults with low IGF-I show greater GH secretion orderliness compared to controls.

P<0.01 and <0.05
n=15

Population

15 subjects: 5 GH-deficient adults with low serum IGF-I concentrations, 5 GHD adults with normal serum IGF-I…

Design

Cross-sectional

Follow-up

24 hours

Authors

JSJohan SvenssonNational Academy of Medicine JVJohannes D. VeldhuisFlorida State University AIAli IranmaneshSalem VA Medical Center

Discussion

Member takes

Implication

Suggests IGF-I modulates GH secretory patterns in GHD; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=15)

Structured PICO

Population

15 adults, comprising 10 with growth hormone deficiency (5 with low IGF-I, 5 with normal IGF-I) and 5 healthy controls, undergoing 24-hour GH profiling.

Outcome

24-h GH profiles (sampling every 30 min) analyzed by deconvolution and approximate entropy (ApEn; regularity) analysessurrogate

Main Result

p-value: p=<0.01 and <0.05

24-h patterns of GH release differ in GHD adults with low vs. normal serum IGF-I concentrations, with low IGF-I patients maintaining greater relative orderliness of GH secretion.

Cite This Study

Svensson et al. (2002) conducted a cross-sectional in Growth Hormone Deficiency (n=15). Low serum IGF-I vs. Normal serum IGF-I and healthy controls was evaluated on Approximate entropy (ApEn) ratios of 24-h GH secretion (p=<0.01 and <0.05). GH-deficient adults with low IGF-I levels exhibited lower ApEn ratios, denoting greater orderliness of GH secretion, compared to those with normal IGF-I and healthy controls (P<0.01 and P<0.05).

synapsesocial.com/papers/6aa6736622b0548423397055 https://doi.org/10.1210/jcem.87.6.8566

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Increased Orderliness of Growth Hormone (GH) Secretion in GH-Deficient Adults with Low Serum Insulin-Like Growth Factor I

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Increased Orderliness of Growth Hormone (GH) Secretion in GH-Deficient Adults with Low Serum Insulin-Like Growth Factor I

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider