Key result
Low IGF-I in growth hormone-deficient adults is linked to more orderly GH secretion.
Population
15 subjects: 5 GH-deficient adults with low serum IGF-I, 5 GHD adults with normal serum IGF-I, and 5 healthy…
Design
Cross-sectional
Follow-up
24 hours
Authors
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Greater orderliness of GH secretion in low-IGF-I GHD; hypothesis-generating for neuroendocrine subtypes and prospective outcome studies.
Cross-Sectional (n=15)
p-value: p=<0.01
GH-deficient adults with low IGF-I exhibit greater relative orderliness of GH secretion compared to those with normal IGF-I, indicating distinct neuroendocrine features.
J. Svensson (2002) conducted a cross-sectional in Growth Hormone Deficiency (n=15). Low serum IGF-I in GH-deficient adults vs. Normal serum IGF-I in GH-deficient adults and healthy controls was evaluated on Approximate entropy (ApEn) ratio of 24-h GH secretion (p=<0.01). Growth hormone-deficient adults with low IGF-I levels exhibited lower approximate entropy ratios, denoting greater orderliness of GH secretion, compared to those with normal IGF-I (P<0.01).
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