Key result
Guanadrel sulfate matches guanethidine or methyldopa for BP reduction with fewer CNS side effects.
Why the study?
Guanadrel sulfate is a postganglionic sympathetic inhibitor with pharmacokinetic differences from guanethidine, and its efficacy and side effect profile in mild to moderate hypertension require evaluation.
Does guanadrel sulfate reduce blood pressure in persons with mild to moderately severe hypertension?
Population
Persons with mild to moderately severe hypertension
Comparison
Guanadrel sulfate vs guanethidine or methyldopa
Design
Review of clinical and animal studies
Authors
Loading...
May offer alternative to guanethidine or methyldopa with fewer CNS effects; leaves open confirmation in contemporary trials.
Does guanadrel sulfate reduce blood pressure in persons with mild to moderately severe hypertension?
Guanadrel sulfate is an effective step 2 antihypertensive agent that serves as a reasonable alternative to guanethidine or methyldopa with potentially fewer central nervous system side effects.
Palmer et al. (1983) conducted a review in Mild to moderate hypertension. Guanadrel sulfate vs. Guanethidine or methyldopa was evaluated on Blood pressure reduction. Guanadrel sulfate is as effective as guanethidine or methyldopa in reducing blood pressure for mild to moderate hypertension, with fewer central nervous system side effects such as drowsiness.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: