Why the study?
Does guanethidine reduce blood pressure in patients with hypertension?
Population
Patients with hypertension, particularly those with severe elevations of diastolic blood pressure
Comparison
Guanethidine vs Ganglion-blocking compounds
Design
Other
Authors
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May support guanethidine as an alternative sympatholytic in severe hypertension; leaves open its role versus modern agents in randomized trials.
Does guanethidine reduce blood pressure in patients with hypertension?
Guanethidine is a promising sympatholytic agent for severe diastolic hypertension, offering effective blood pressure reduction with fewer side effects than ganglion-blocking drugs.
Brest et al. (1961) studied this question.
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