Why the study?
Does bethanidine compared to guanethidine improve blood pressure control in patients with severe hypertension on hydrochlorothiazide?
Population
108 patients with severe hypertension
Comparison
Bethanidine added to hydrochlorothiazide vs Guanethidine added to hydrochlorothiazide
Design
RCT, assigned randomly, double-blind
Follow-up
6 months
Authors
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Supports preferring guanethidine over bethanidine for severe hypertension; confirms RCT superiority in diastolic BP reduction.
Does bethanidine compared to guanethidine improve blood pressure control in patients with severe hypertension on hydrochlorothiazide?
Guanethidine provides significantly better diastolic blood pressure control than bethanidine in patients with severe hypertension on hydrochlorothiazide.
Ramírez et al. (1977) studied this question.
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