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February 18, 1961JAMA

A Study of 38 Patients and Their Responses to Guanethidine

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Why the study?

Does guanethidine reduce blood pressure in patients with varying degrees of hypertension?

Population

38 patients with various degrees of hypertension, including 10 with symptoms classified as severe and 4…

Comparison

Guanethidine, total daily dosage ranging from 10… vs Placebo medication for 8 weeks before commencing…

Design

Case_series, Patients were not informed of the change from placebo to…

Authors

JEJ. EaganPurdue University Northwest

Discussion

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Implication

Variable BP responses to guanethidine in this case report warrant caution; hypothesis-generating for controlled trials.

Structured PICO

Does guanethidine reduce blood pressure in patients with varying degrees of hypertension?

P
Population
38 patients with various degrees of hypertension, including 10 with symptoms classified as severe and 4 classified as malignant.
I
Intervention
Guanethidine, total daily dosage ranging from 10 to 400 mg divided into 2 to 4 doses per day. Some antihypertensive measures, such as restriction of salt intake, were continued.
C
Comparator
Placebo medication for 8 weeks before commencing guanethidine (sequential/self-controlled design).
O
Outcome
Fall in calculated mean blood pressure (recumbent and erect).surrogate

Guanethidine effectively lowers both recumbent and erect blood pressure in hypertensive patients, though individual responses vary and side effects are common.

Cite This Study

J. Eagan (1961) studied this question.

synapsesocial.com/papers/6a8beb2b9d5fb440a3bebf64https://doi.org/10.1001/jama.1961.03040070008002

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of antihypertensive efficacy, intestinal absorption, and excretion of guanethidine in hypertensive patients1969 · 22 citations
  2. 2Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine.1976 · 52 citations
  3. 3Multiclinic controlled trial of bethanidine and guanethidine in severe hypertension.1977 · 16 citations
  4. 4The relationship of plasma guanethidine levels to adrenergic blockade1975 · 19 citations
  5. 5Comparison of guanadrel and guanethidine1973 · 20 citations