Key result
Poor intestinal absorption fails to explain inadequate guanethidine response.
Why the study?
The cause of inadequate response to guanethidine in hypertensive patients was unclear, specifically whether poor intestinal absorption contributed.
Does intestinal absorption or urinary excretion of guanethidine differ between responders and non-responders in patients with essential hypertension?
Population
6 patients with essential hypertension
Comparison
Responders to 25 mg/day guanethidine vs non-responders to 150 mg/day guanethidine
Design
Observational study measuring intestinal absorption and urinary excretion
Authors
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Excludes malabsorption as cause of guanethidine nonresponse; leaves open alternative mechanisms for variable effect in hypertension.
Observational (n=6)
Does intestinal absorption or urinary excretion of guanethidine differ between responders and non-responders in patients with essential hypertension?
Poor intestinal absorption is not the underlying cause of inadequate antihypertensive response to guanethidine in patients with essential hypertension.
Rahn et al. (1969) conducted an observational in Essential hypertension (n=6). Guanethidine-14C vs. Responders vs Non-responders was evaluated on Intestinal absorption and urinary excretion of guanethidine (radioactivity in urine and feces). Poor intestinal absorption was not the cause of inadequate response to guanethidine, as urinary and fecal excretion of radioactivity were similar between responders and non-responders.
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