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July 1, 1976CirculationOpen Access

Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine.

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Why the study?

Does guanethidine reduce blood pressure and improve side effect profiles compared to reserpine in patients with mild to moderate hypertension?

Population

49 ambulant patients with mild to moderate hypertension treated with hydrochlorothiazide.

Comparison

Guanethidine added in graded increments to… vs Reserpine added in graded increments to…

Design

RCT, double blind

Authors

RFR FergusonPublic Health EnglandRRR.J. RothenbergOhio UniversityANAlan S. NiesMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

Supports guanethidine for mild-moderate hypertension; challenges prior restriction to severe cases only.

Structured PICO

Does guanethidine reduce blood pressure and improve side effect profiles compared to reserpine in patients with mild to moderate hypertension?

P
Population
49 ambulant patients (30 men, 19 women) with mild to moderate hypertension (diastolic pressure 95-115 mm Hg) treated with hydrochlorothiazide.
I
Intervention
Guanethidine added in graded increments to background hydrochlorothiazide 50 mg/day.
C
Comparator
Reserpine added in graded increments to background hydrochlorothiazide 50 mg/day.
O
Outcome
Blood pressure measurements and side effect scores evaluated biweekly.surrogate

Guanethidine is effective and well-tolerated for mild to moderate hypertension, refuting the belief that it should be reserved only for severe hypertension.

Cite This Study

Ferguson et al. (1976) studied this question.

synapsesocial.com/papers/6a7d40cdff1a536db837d571https://doi.org/10.1161/01.cir.54.1.32

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Study of 38 Patients and Their Responses to Guanethidine1961 · 5 citations
  2. 2Multiclinic controlled trial of bethanidine and guanethidine in severe hypertension.1977 · 16 citations
  3. 3Comparison of antihypertensive efficacy, intestinal absorption, and excretion of guanethidine in hypertensive patients1969 · 22 citations
  4. 4Comparison of guanadrel and guanethidine1973 · 20 citations
  5. 5Guanadrel Sulfate: A Postganglionic Sympathetic Inhibitor for the Treatment of Mild to Moderate Hypertension1983 · 8 citations