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March 1, 1973Clinical Pharmacology & TherapeuticsOpen Access

Comparison of guanadrel and guanethidine

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Why the study?

Does guanadrel improve blood pressure control compared to guanethidine and placebo?

Comparison

Guanadrel vs Guanethidine and placebo

Design

Other

Authors

LHLennart HanssonGeneral CardiologyAPArturo PascualWestchester Medical CenterSJStevo JuliusUppsala University

Discussion

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Implication

Both agents lower BP versus placebo with equivalent potency; hypothesis-generating for guanadrel's role in contemporary hypertension management.

Structured PICO

Does guanadrel improve blood pressure control compared to guanethidine and placebo?

I
Intervention
Guanadrel
C
Comparator
Guanethidine and placebo
O
Outcome
Reduction of blood pressuresurrogate

Guanadrel provides similar antihypertensive potency to guanethidine but offers better all-day blood pressure control and a more favorable side effect profile.

Cite This Study

Hansson et al. (1973) studied this question.

synapsesocial.com/papers/6a838829b59abb3f3b30736fhttps://doi.org/10.1002/cpt1973142204

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Guanadrel Sulfate: A Postganglionic Sympathetic Inhibitor for the Treatment of Mild to Moderate Hypertension1983 · 8 citations
  2. 2A Study of 38 Patients and Their Responses to Guanethidine1961 · 5 citations
  3. 3Comparison of antihypertensive efficacy, intestinal absorption, and excretion of guanethidine in hypertensive patients1969 · 22 citations
  4. 4Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine.1976 · 52 citations
  5. 5Multiclinic controlled trial of bethanidine and guanethidine in severe hypertension.1977 · 16 citations