A generalized activating function for predicting virtual electrodes in cardiac tissue
Key result
New generalized activating function successfully predicts virtual electrode effects and membrane polarizations in cardiac simulations.
Why the study?
To fully understand the mechanisms of defibrillation, understanding how an electrical stimulus causes membrane polarizations in cardiac tissue is critical.
Population
Two-dimensional sheet of passive myocardium under steady-state conditions
Comparison
Assumed extracellular potential distribution vs fully coupled intra- and extracellular domains
Design
Computer simulation study
Authors
Discussion
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Member takes
Implication
Simulation framework for virtual electrodes; leaves open validation in active tissue and clinical defibrillation.
Structured PICO
P
Population
Computer simulations of a two-dimensional sheet of passive myocardium
I
Intervention
Generalized activating function to predict virtual electrodes
C
Comparator
Assumed extracellular potential distribution versus fully coupled intra- and extracellular domains
O
Outcome
Prediction of virtual electrodes and membrane polarizations in cardiac tissue
The derived generalized activating function provides a useful theoretical framework for understanding virtual electrode effects and defibrillation mechanisms in cardiac tissue.
Cite This Study
Sobie et al. (1997) studied Cardiac tissue electrophysiology. Generalized activating function model was evaluated on Prediction of virtual electrodes and membrane polarizations. A newly derived generalized activating function successfully predicted virtual electrode effects and membrane polarizations in computer simulations of passive cardiac tissue.