Key result
Unilateral stimulation of the vagus nerve dorsal motor nucleus rapidly increases plasma insulin ~200% in rats.
Why the study?
The physiological role of the dorsal motor nucleus of the vagus nerve in regulating insulin release via vagal fibers was investigated to understand its connection to the endocrine pancreas.
Does electrical stimulation of the dorsal motor nucleus of the vagus nerve increase plasma insulin levels in normal anesthetized rats?
Population
Normal anesthetized rats
Comparison
Unilateral electrical stimulation of DMX vs no stimulation
Design
Preclinical experimental study with electrical stimulation
Authors
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Extends preclinical evidence for vagal insulin control; leaves open translation to human metabolic therapies.
Does electrical stimulation of the dorsal motor nucleus of the vagus nerve increase plasma insulin levels in normal anesthetized rats?
Effect estimate: ≥200% increase
The dorsal motor nucleus of the vagus nerve is connected to the endocrine pancreas exclusively via vagal fibers and plays a role in neurally mediated insulin release.
Ionescu et al. (1983) studied Normal anesthetized rats. Unilateral electrical stimulation of the dorsal motor nucleus of the vagus nerve (DMX) was evaluated on Plasma insulin levels (≥200% increase). Unilateral electrical stimulation of the dorsal motor nucleus of the vagus nerve in normal anesthetized rats resulted in a rapid rise in plasma insulin levels of ≥200%.
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