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September 15, 2026European Heart Journal Supplements

Cardiac Contractility Modulation (Ccm) Therapy: An Emblematic Case of Reduced Hospitalizations for Heart Failure

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Key result

CCM therapy improves NYHA class and reduces NT-proBNP in a severe heart failure case.

  • n=1

Why the study?

Cardiac contractility modulation therapy appears to act at cellular and molecular levels altered in heart failure, but clinical experience remains limited.

Population

73-year-old man with severe left ventricular dysfunction and recurrent acute decompensated heart failure

Comparison

CCM therapy active versus inactive (battery depletion) periods

Design

Case report

Authors

MDM DadamoRVR ValecceCVC Volpe

Discussion

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Overview

Case of CCM in post-MI HF with ICD supports further exploration; leaves open efficacy and safety in controlled trials.

Key Points

  • To assess the clinical impact of cardiac contractility modulation therapy on hospitalizations, functional capacity, and biomarker profiles in persistent severe left ventricular dysfunction.
  • Case report of a 73-year-old male with ischemic cardiomyopathy, severely depressed left ventricular ejection fraction (25%), and multiple admissions for acute decompensated heart failure and cardiogenic shock.
  • Implantation of a cardiac contractility modulation device using two right interventricular septal leads, evaluated across regular clinical, echocardiographic, and biomarker assessments.
  • Active cardiac contractility modulation eliminated heart failure hospitalizations, improved functional capacity by at least one NYHA class, reduced systolic pulmonary artery pressure from 65 mmHg to 45 mmHg, and decreased ventricular arrhythmic burden.
  • Device generator battery depletion after one month without recharging triggered acute heart failure exacerbation with NT-proBNP surging to 25,062 pg/mL, which fully resolved upon device reactivation and diuretic therapy.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 73-year-old man with severe left ventricular dysfunction and recurrent acute decompensated heart failure.
I
Intervention
Cardiac contractility modulation (CCM) device implantation with two ventricular leads on the right interventricular septum
O
Outcome
Clinical status, heart failure hospitalizations, NYHA functional class, and NT-proBNP levels

Cardiac contractility modulation therapy provided sustained clinical improvement and reduced hospitalizations in a patient with severe left ventricular dysfunction.

Cite This Study

Dadamo et al. (2026) conducted a case report in Heart failure (n=1). Cardiac contractility modulation (CCM) therapy was evaluated. Cardiac contractility modulation therapy improved clinical status by at least one NYHA functional class and reduced NT-proBNP levels in a 73-year-old man with severe heart failure.

synapsesocial.com/papers/6aa9016aeed42882c1fc1833https://doi.org/10.1093/eurheartjsupp/suag058.328
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1QUALITY OF LIFE IMPROVEMENT AND REDUCTION IN HOSPITALIZATIONS IN PATIENTS WITH HEART FAILURE UNDERGOING CARDIAC CONTRACTILITY MODULATION (CCM) THERAPY: A SINGLE–CENTER EXPERIENCE2026
  2. 2CARDIAC CONTRACTILITY MODULATION: AN OPTION FOR CHRONIC HEART FAILURE; A CASE REPORT2024 · 1 citations
  3. 3USE OF CARDIAC CONTRACTILITY MODULATION: OUR EXPERIENCE2024
  4. 4Dependence on Cardiac Contractility Modulation Therapy: Loss of Continuous and Effective Modulation as a Cause of Heart Failure Exacerbation2026
  5. 5NON–INVASIVE ASSESSMENT OF FUNCTIONAL PARAMETERS AFTER THE IMPLANTATION OF A CCM2026