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September 15, 2026European Heart Journal Supplements

Non–invasive Assessment of Functional Parameters After the Implantation of a CCM

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Key result

CCM improves MLHFQ score by 20 points and reduces pacing in a heart failure case.

  • n=1

Why the study?

Does cardiac contractility modulation (CCM) improve symptoms and congestion in a patient with non-ischemic dilated cardiomyopathy on optimal medical therapy?

Population

1 72-year-old female with non-ischemic dilated cardiomyopathy, persistent dyspnea despite optimized medical…

Design

Case_report

Follow-up

6 months

Authors

FFF Di FraiaUniversity of SalernoDMD Di MaioUniversity of SalernoAVA VarricchioUniversity of Salerno

Discussion

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Implication

Persistent symptoms despite quadruple GDMT plus vericiguat in non-ischemic DCM; leaves open optimal sequencing and adjunctive strategies.

Key Points

  • To evaluate functional parameters and continuous non-invasive device diagnostics following cardiac contractility modulation therapy in a patient with refractory heart failure.
  • A 72-year-old female with non-ischemic dilated cardiomyopathy (ejection fraction 30%), permanent atrial fibrillation, and a dual-chamber defibrillator underwent right-sided cardiac contractility modulation (CCM) implantation.
  • Follow-up assessments were conducted at 1 and 6 months using clinical examination, echocardiography, the Minnesota Living with Heart Failure Questionnaire (MLHFQ), and defibrillator diagnostic trends.
  • Minnesota Living with Heart Failure Questionnaire scores improved from 60 at baseline and 1 month to 40 at 6 months, accompanied by symptom reduction and complete cessation of furosemide diuretic therapy.
  • Defibrillator diagnostic trends demonstrated a marked reduction in intrathoracic fluid (OptiVol) and decreased ventricular pacing percentage, while echocardiographic parameters and daily activity hours showed no significant changes.

Study Design

Type

Case Report (n=1)

Structured PICO

Does cardiac contractility modulation (CCM) improve symptoms and congestion in a patient with non-ischemic dilated cardiomyopathy on optimal medical therapy?

P
Population
A 72-year-old female with non-ischemic dilated cardiomyopathy and persistent dyspnea despite optimized medical therapy followed for 6 months after CCM implantation.
I
Intervention
Cardiac contractility modulation (CCM) therapy implanted on the right side.
O
Outcome
Clinical improvement assessed by Minnesota Living with Heart Failure Questionnaire (MLHFQ), echocardiogram, and device diagnostic parameters (OptiVol, daily ventricular pacing) at 6 months.patient reported

CCM therapy may provide symptomatic relief and reduce congestion, as evidenced by continuous device monitoring, in patients with heart failure who remain symptomatic despite optimal medical therapy.

Cite This Study

Fraia et al. (2026) conducted a case report in Non-ischemic dilated cardiomyopathy (n=1). Cardiac contractility modulation (CCM) therapy was evaluated on Minnesota Living with Heart Failure Questionnaire (MLHFQ) score and device diagnostic parameters. Cardiac contractility modulation therapy in a 72-year-old female with heart failure improved the MLHFQ score from 60 to 40 at 6 months and reduced intracorporeal fluid and ventricular pacing.

synapsesocial.com/papers/6aa9016aeed42882c1fc1869https://doi.org/10.1093/eurheartjsupp/suag058.326

Topics

Heart failureHFrEF treatmentAtrial fibrillationPersistent AF managementHeart failure hospitalization
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CARDIAC CONTRACTILITY MODULATION (CCM) THERAPY: AN EMBLEMATIC CASE OF REDUCED HOSPITALIZATIONS FOR HEART FAILURE2026
  2. 2USE OF CARDIAC CONTRACTILITY MODULATION: OUR EXPERIENCE2024
  3. 3QUALITY OF LIFE IMPROVEMENT AND REDUCTION IN HOSPITALIZATIONS IN PATIENTS WITH HEART FAILURE UNDERGOING CARDIAC CONTRACTILITY MODULATION (CCM) THERAPY: A SINGLE–CENTER EXPERIENCE2026
  4. 4CARDIAC CONTRACTILITY MODULATION: AN OPTION FOR CHRONIC HEART FAILURE; A CASE REPORT2024 · 1 citations
  5. 5A56-10 Effectiveness of Cardiac Contractility Modulation Device in Management of Chronic Heart Failure2026