Key result
More leads with fragmented QRS predict ~39% lower odds of CRT response.
Why the study?
The relationship between the number of leads with fragmented QRS and response to cardiac resynchronization therapy had not been investigated.
Does the number of leads with fragmented QRS predict echocardiographic response to cardiac resynchronization therapy in patients with heart failure?
Comparison
Number of leads with fragmented QRS
Design
Prospective cohort study
Follow-up
6 months
Authors
Loading...
May warrant caution when selecting CRT candidates with multiple fQRS leads; leaves open prospective validation of this marker.
Cohort (n=105)
Does the number of leads with fragmented QRS predict echocardiographic response to cardiac resynchronization therapy in patients with heart failure?
Odds Ratio: 0.61 (95% CI 0.48–0.77)
p-value: p=< 0.001
A higher number of leads with fragmented QRS on baseline electrocardiogram predicts a lower likelihood of echocardiographic response to cardiac resynchronization therapy.
Çelikyurt et al. (2012) conducted a cohort in Heart failure (n=105). Number of leads with fragmented QRS (fQRS) was evaluated on Echocardiographic response to CRT defined by a ≥15% reduction in left ventricular end-systolic volume at 6 months follow-up (OR 0.61, 95% CI 0.48-0.77, p=< 0.001). A higher number of leads with fragmented QRS predicted nonresponse to cardiac resynchronization therapy (OR 0.61; 95% CI 0.48-0.77; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: