Key result
Female sex links to lower long-term post-TAVR mortality despite higher bleeding and vascular complications.
Why the study?
Are there sex-related differences in outcomes following transcatheter aortic valve replacement for severe aortic stenosis?
Are there sex-related differences in outcomes following transcatheter aortic valve replacement for severe aortic stenosis?
Females undergoing TAVR for severe aortic stenosis experience better intermediate and long-term survival than males, despite a higher risk of periprocedural complications.
May guide sex-specific TAVR risk discussions; leaves open mechanisms and need for prospective validation.
Females exhibit differences in morphologic, hemodynamic and ventricular response to progressive aortic stenosis (AS), with better overall survival rates compared with males. In addition, females and males differ in baseline characteristics at the time of intervention for symptomatic severe AS. Females have a higher risk of death with surgical aortic valve replacement compared with males. Despite higher incidences of vascular complications, major bleeding and possibly strokes with transcatheter aortic valve replacement, females had better intermediate and long-term mortality compared with males. This review will summarize the data on sex differences in AS and transcatheter aortic valve replacement outcomes.
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Rebecca T. Hahn (2015) conducted a review in Aortic stenosis. Female sex vs. Male sex was evaluated. Female sex is associated with better intermediate and long-term mortality after transcatheter aortic valve replacement compared with males, despite higher rates of vascular complications and bleeding.
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