Key result
Breeding in hypertensive rats induces sudden death driven by myocardial necrosis and congestive heart failure.
Why the study?
The mechanisms by which reproductive effort influences myocardial necrosis and hypertensive arteriopathy in spontaneously hypertensive stroke-prone rats were unclear.
Does breeding induce myocardial necrosis and sudden death in stroke-prone spontaneously hypertensive rats?
Does breeding induce myocardial necrosis and sudden death in stroke-prone spontaneously hypertensive rats?
Breeding in stroke-prone spontaneously hypertensive rats alters hypothalamic-pituitary-adrenal function, leading to myocardial necrosis and sudden death rather than stroke.
Breeding confounds stroke models in hypertensive rats; leaves open human relevance of HPA-driven cardiac mortality.
Virgin and breeder, spontaneously hypertensive and stroke prone rats (SHR/SP) were observed from weaning until 130 +/- 10 days of age. Blood pressure rose rapidly, reaching 230--240 mm Hg. After the birth of the second litter of pups, male and female breeders began to die suddenly, due to myocardial necrosis and congestive heart failure. At autopsy, the brains of virgin and breeder SHR/SP were swollen but were free of any pathologic changes. There were no significant alterations in the blood chemistry of virgin rats but breeder SHR/SP had super-normal enzyme levels, CPK, SGOT, SGPT and LDH, hyperglycemia, hyperlipidemia, and hypersecretion of corticosterone. Breeder SHR/SP developed PAN-like lesions of the mesenteric arcades and adrenal cortex along with severe fibrino-hyalin lesions of the testicular and ovarian arteries. It is suggested that alterations in hypothalamic-pituitary-adrenal function associated with the reproductive effort conditioned these SHR/SP to develop myocardial necrosis rather than stroke and the development of unusual hypertensive arteriopathy.
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Bernard C. Wexler (1980) studied Spontaneously hypertensive and stroke-prone rats (SHR/SP). Breeding (reproductive effort) vs. Virgin rats was evaluated on Myocardial necrosis and sudden death. Breeding in spontaneously hypertensive and stroke-prone rats induced sudden death due to myocardial necrosis and congestive heart failure, accompanied by elevated enzymes and corticosterone.
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