Key result
Left bundle branch pacing successfully restored left ventricular ejection fraction from 40-45% to 60-64% in a heart transplant recipient with right ventricular pacing-induced cardiomyopathy.
Why the study?
The optimal cardiac pacing method after orthotopic heart transplantation is largely unexplored, especially regarding pacing-induced cardiomyopathy risk.
Does left bundle branch pacing improve left ventricular function and reverse pacing-induced cardiomyopathy in orthotropic heart transplant recipients?
Case Report (n=1)
Does left bundle branch pacing improve left ventricular function and reverse pacing-induced cardiomyopathy in orthotropic heart transplant recipients?
Left bundle branch pacing safely and effectively reversed right ventricular pacing-induced cardiomyopathy in an orthotropic heart transplant recipient.
May offer corrective pacing option in transplant recipients with cardiomyopathy; leaves open confirmation in prospective studies.
BACKGROUND: Atrioventricular (AV) block is a potential complication of orthotropic heart transplantation (OHT). The optimal cardiac pacing method is largely unexplored in patients after OHT. CASE SUMMARY: We present a patient with AV block after OHT in whom right ventricular pacing resulted in pacing-induced cardiomyopathy (PICM). Left ventricular function was restored with left bundle branch pacing. DISCUSSION: AV block is an uncommon complication after OHT that requires ventricular pacing. Ventricular dyssynchrony induced by right ventricular pacing may be associated with increased risk for PICM in OHT recipients. Cardiac physiologic pacing should be considered as the primary pacing strategy in this population. TAKE-HOME MESSAGES: OHT recipients may be at increased risk for PICM. Left bundle branch pacing is an effective strategy for both prevention and treatment of PICM.
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Tomassoni et al. (2025) conducted a case report in Pacing-induced cardiomyopathy in an orthotopic heart transplant recipient (n=1). Left bundle branch pacing vs. Right ventricular pacing (pre-upgrade) was evaluated on Left ventricular ejection fraction. Left bundle branch pacing successfully restored left ventricular ejection fraction from 40-45% to 60-64% in a heart transplant recipient with right ventricular pacing-induced cardiomyopathy.
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