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June 19, 2022Tropical Journal of Pharmaceutical ResearchOpen Access

Modified Wenyang Buxin decoction combined with routine therapy significantly improved left ventricular ejection fraction (58.98% vs 50.11%, p<0.001) compared to routine therapy alone in patients with chronic heart failure.

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Why the study?

Does modified Wenyang Buxin decoction added to routine therapy improve cardiac function and serum biomarkers in chronic heart failure patients?

Population

120 chronic heart failure (CHF) patients admitted to Zhejiang Province Rongjun Hospital

Comparison

150 mL of modified Wenyang Buxin decoction daily… vs Routine therapy

Design

RCT, randomly but equally distributed

Follow-up

2 months

Key result

Modified Wenyang Buxin decoction combined with routine therapy significantly improved left ventricular ejection fraction (58.98% vs 50.11%, p<0.001) compared to routine therapy alone in patients with chronic heart failure.

Authors

CQChengsi QianYSYan Sun

Discussion

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Overview

May improve biomarkers and function as adjunct in small RCT; leaves open efficacy in larger outcome trials.

Study Design

Type

RCT (n=120)

Randomization

Random number table

Multicenter

No

Structured PICO

Does modified Wenyang Buxin decoction added to routine therapy improve cardiac function and serum biomarkers in chronic heart failure patients?

P
Population
120 patients aged 52-74 years with chronic heart failure (NYHA class II-IV) treated for 2 months.
I
Intervention
150 mL of modified Wenyang Buxin decoction daily added to routine therapy (diuretic treatment and detumescence) for 2 months
C
Comparator
Routine therapy (diuretic treatment and detumescence)
O
Outcome
Cardiac function indices, serum H-FABP, cTnI and Ang-2 levels, hemorheology indices, traditional Chinese medicine (TCM) syndrome scores, and Chinese questionnaire of quality of life in cardiovascular patients (CQQC) scores at 2 monthssurrogate

Main Result

Absolute Event Rate: 58.98% vs 50.11%

p-value: p=<0.001

Modified Wenyang Buxin decoction added to routine therapy may improve cardiac function, biomarker profiles, and quality of life in patients with chronic heart failure.

Limitations

  • Whether this kind of drug for blood circulation should be indiscriminately applied to all patients still needs further research

Cite This Study

Qian et al. (2022) conducted an RCT in Chronic heart failure (CHF) (n=120). Modified Wenyang Buxin decoction vs. Routine therapy was evaluated on Left ventricle ejection fraction (LVEF) (p=<0.001). Modified Wenyang Buxin decoction combined with routine therapy significantly improved left ventricular ejection fraction (58.98% vs 50.11%, p<0.001) compared to routine therapy alone in patients with chronic heart failure.

synapsesocial.com/papers/6ab0e640105bfbee92ff6c63https://doi.org/10.4314/tjpr.v21i5.28
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of Zhen Wu Decoction against chronic heart failure2021 · 2 citations
  2. 2Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure: a prospective, single-blind, randomized, controlled, and multicenter clinical trial2017 · 20 citations
  3. 3Traditional Chinese medicine as an adjunctive therapy improves cardiac function and reduces serum inflammatory markers in patients with chronic heart failure2024 · 3 citations
  4. 4Chinese herbal medicine for chronic heart failure: a multicenter, randomized, double-blind, placebo-controlled trial2014 · 11 citations
  5. 5The Impact of Buzhong Yiqi Decoction Combined with Xuefu Zhuyu Decoction on Cardiac Function and Quality of Life in Patients with Coronary Heart Disease and Heart Failure2025