Key result
Tiamenidine cuts blood pressure ~15% matching clonidine, with similar rebound upon withdrawal.
Why the study?
The effects of tiamenidine and clonidine on blood pressure, plasma catecholamines, and plasma renin activity in hypertensive patients were assessed to compare their pharmacology.
Does tiamenidine compared to clonidine reduce blood pressure and catecholamines in previously untreated male hypertensive patients?
Population
4 previously untreated male hypertensive patients
Comparison
Tiamenidine (max 3 mg daily) vs clonidine (max 450 micrograms daily)
Design
Cross-over study
Authors
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May warrant clonidine-like withdrawal monitoring; leaves open any long-term advantage in larger hypertensive populations.
Does tiamenidine compared to clonidine reduce blood pressure and catecholamines in previously untreated male hypertensive patients?
Tiamenidine and clonidine both effectively lower blood pressure and catecholamines, but their withdrawal causes significant rebound hypertension and catecholamine surges.
Bg et al. (1981) studied hypertension (n=4). Tiamenidine vs. Clonidine was evaluated on blood pressure, plasma noradrenaline, plasma adrenaline, urinary catecholamines and plasma renin activity. Tiamenidine and clonidine both reduced blood pressure by 12-15% during treatment, with similar rebound effects overshooting baseline levels upon withdrawal.
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