Key result
Major surgery significantly increased plasma endothelin levels compared to baseline (P<0.05), whereas minor surgery did not, with levels correlating with blood loss and operation duration.
Why the study?
Does major surgery under general anesthesia increase plasma endothelin levels in surgical patients?
Population
100 patients undergoing various kinds of surgery under general anesthesia
Comparison
Major surgery under general anesthesia vs Minor surgery or baseline (before surgery)
Design
Cohort
Follow-up
up to a few hours after surgery
Authors
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Major surgery is associated with elevated endothelin levels correlating with blood loss; leaves open its value as a perioperative biomarker pending outcome studies.
Observational (n=100)
Does major surgery under general anesthesia increase plasma endothelin levels in surgical patients?
p-value: p=< 0.05
Plasma endothelin levels increase gradually during major surgery, correlating with blood loss and operation duration, but do not increase during minor surgery or anesthesia alone.
Shirakami et al. (1995) conducted an observational in Patients undergoing surgery under general anesthesia (n=100). Major surgery vs. Baseline (before surgery) and minor surgery was evaluated on Plasma ET-like immunoreactivity (ET-LI) levels (p=< 0.05). Major surgery significantly increased plasma endothelin levels compared to baseline (P<0.05), whereas minor surgery did not, with levels correlating with blood loss and operation duration.
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