April 1, 1999Anesthesia & Analgesia
Perioperative Plasma Endothelin-1 and Big Endothelin-1 Concentrations in Elderly Patients Undergoing Major Surgical Procedures
Why the study?
Does normothermic perioperative care compared to hypothermic care affect plasma ET-1 and Big ET-1 concentrations in elderly patients undergoing major surgery?
Population
95 consecutive elderly patients (mean age 70 +/- 1 yr) undergoing major surgical procedures
Comparison
Normothermic perioperative care vs Hypothermic perioperative care
Design
RCT, Randomized to receive either normothermic or hypothermic perioperative care
Follow-up
Perioperative and postoperative period
Authors
Discussion
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Member takes
Implication
Mild perioperative hypothermia does not alter ET-1 or Big ET-1 levels; confirms thermoregulatory vasoconstriction occurs independently of the endothelin system.
Structured PICO
Does normothermic perioperative care compared to hypothermic care affect plasma ET-1 and Big ET-1 concentrations in elderly patients undergoing major surgery?
P
Population
95 consecutive elderly patients (mean age 70 +/- 1 yr) undergoing major surgical procedures
I
Intervention
Normothermic perioperative care
C
Comparator
Hypothermic perioperative care
O
Outcome
Plasma endothelin-1 (ET-1) and Big ET-1 concentrations at several perioperative time pointssurrogate
Big ET-1 is a more sensitive measure of endothelin system activation after major surgery than ET-1, and thermoregulatory vasoconstriction in response to mild perioperative hypothermia occurs independently of the endothelin system.
Cite This Study
Nelson et al. (1999) studied this question.