April 1, 1999Anesthesia & Analgesia
Perioperative Plasma Endothelin-1 and Big Endothelin-1 Concentrations in Elderly Patients Undergoing Major Surgical Procedures
Key result
Normothermic perioperative care compared with hypothermic care resulted in no significant differences in mean ET-1 or Big ET-1 levels in elderly patients undergoing major surgery.
Why the study?
Does normothermic perioperative care compared to hypothermic care alter plasma ET-1 and Big ET-1 concentrations in elderly patients undergoing major surgical procedures?
Population
95 consecutive elderly patients (mean age 70 +/- 1 yr) undergoing major surgical procedures
Comparison
Normothermic perioperative care vs Hypothermic perioperative care
Design
RCT, Randomized to receive either normothermic or hypothermic perioperative care
Follow-up
Perioperative and postoperative period
Authors
Discussion
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Implication
Mild perioperative hypothermia does not engage the endothelin system; confirms thermoregulatory vasoconstriction occurs independently in elderly major surgery patients.
Study Design
Type
RCT (n=95)
Randomization
randomized
Structured PICO
Does normothermic perioperative care compared to hypothermic care alter plasma ET-1 and Big ET-1 concentrations in elderly patients undergoing major surgical procedures?
P
Population
95 elderly patients (mean age 70 years) undergoing major surgical procedures.
I
Intervention
Normothermic perioperative care
C
Comparator
Hypothermic perioperative care
O
Outcome
Plasma concentrations of ET-1 and Big ET-1 at several perioperative time pointssurrogate
Big ET-1 is a more sensitive measure of endothelin system activation after major surgery than ET-1, and thermoregulatory vasoconstriction in response to mild perioperative hypothermia occurs independently of the endothelin system.
Cite This Study
Nelson et al. (1999) conducted an RCT in Undergoing major surgical procedures (n=95). Normothermic perioperative care vs. Hypothermic perioperative care was evaluated on Mean ET-1 and Big ET-1 levels. Normothermic perioperative care compared with hypothermic care resulted in no significant differences in mean ET-1 or Big ET-1 levels in elderly patients undergoing major surgery.